Incidental Liver Lesions



people are living with liver and intrahepatic bile duct cancer in the U.S.


5-year survival rate if detected when localized

Liver Cancer Screening

  • Adults over 16 with cirrhosis of the liver
  • Adults over 16 with chronic hepatitis B viral infection
  • Adults over 16 with chronic hepatitis C viral infection
LI-RADSDefinition and Follow-up
NegativeNo observations detected; surveillance in 6 months
LR-NCNot categorizable due to image omission or degradation; repeat or alternative imaging in ≤ 3 months
1Definitely benign; surveillance in 6 months
2Probably benign; consider repeat diagnostic imaging in 6 months
3Intermediate probability of malignancy; repeat or alternative imaging in 3–6 months
4Probably HCC; multidisciplinary discussion for further work-up
5Definitely HCC; multidisciplinary discussion for management consensus
LR-MProbably/definite malignancy not HCC specific; multidisciplinary discussion, consider biopsy
LR-TIVDefinite tumor in vein; multidisciplinary discussion, may include biopsy

Incidental Liver Lesion Identification

The Only Total Solution For All Liver Patients

EPM Liver was designed for a comprehensive liver program:

  • Does not disrupt radiology workflow or require change in radiologist interpretation or documentation
  • Extracts finding size, number of findings, and location of largest abnormality
  • Automates tracking for all patients and all LI-RADS in one dashboard
  • Listens for pertinent follow-up exams, including unscheduled and emergency
  • Automates FTE workflow with evidence-based follow-up logic
  • Standard reports are available for download

Liver Cancer In The U.S.


hospital FTEs workload is not related to patient care


of healthcare tasks can be automated

Dr. Erika Schneider, Ph.D.Vice President, Product and Chief Science Officer, Eon

“EPM uses our newest CL model to automatically identify incidental liver lesions. The model has a high overall accuracy at 94%, which will improve as we continue to augment the data sets. The new Liver cohort enhances the Eon oncology portfolio by allowing earlier detection and treatment of primary liver cancers as well as metastases from other malignancies.”

Navigators & Coordinators

  • Automate longitudinal care coordination
  • Prioritize the higher-risk patient populations
  • Receive notifications for patients who need diagnostic workup or who missed their scheduled follow-ups
  • Automate and trigger follow-up communication

Providers & Clinicians

  • Capture incidental liver lesions
  • Screen eligible patients, track through to treatment
  • Integrate pathology information
  • Ensure adherence and follow-up
  • Improve patient outcomes


  • No disruption in workflow
  • No mandated structured report
  • Patient follow-up adherence

Hospital Executives

  • Capture more patients, reduce leakage
  • Drive downstream revenue
  • Optimize FTEs and focus on patient care


CL consists of industry-best data science models that understand text and the linguistic structure of medical English similar to the human brain. The Eon CL Liver model identifies incidental liver findings in radiology reports with 94.2% accuracy. As a part of EPM Liver, CL can:

  • Identify a mass, nodule, lesion, cyst, enhancing area/region, or hemangioma with a measurement in a radiology report and documents its maximum diameter. Postoperative seromas and hamartomas are excluded, as are fatty or fibrotic liver disease.
  • Allow a few false positive patients who don’t really have liver disease to enter the system (which can be manually discarded from the incoming worklist) while simultaneously limiting the number of false negatives, resulting in fewer missed patients with real liver disease.

Longitudinal Tracking

EPM’s sophisticated business logic implements the evidence-based guidance needed to manage patient follow-up to increase adherence and maximize the value of your program:

  • Enables reminders for exams and procedures so your liver team knows who has been scheduled and who missed their exams
  • Prioritize patients who are high-risk (LI-RADS 4, 5, LR-M, LR-TIV) and need immediate care coordination, while automating follow-up for the low-risk (LI-RADS 1, 2, 3) patients
  • Use Eon’s proprietary “Follow-Up Listener” to automatically track patients and identify those patients who have had their exams or procedures and who are at risk for no follow-up


Glean real-time insight into your liver program with real-time analytics.

  • View key metrics and activity by tracking trends and measuring program growth
  • See complex patient management data in a whole new way
  • Increases capture, drive downstream revenue, and prove program ROI


Automate, track, and archive communication from one convenient location. Get all documentation done from an easy-to-use dashboard.

  • Use proprietary logic to automate patient and provider communication
  • Create unlimited custom letters with drag and drop tools
  • Track who has been contacted, when they were contacted, and how they contacted
  • Consolidate all contact information and always know who and when to contact—with the right information at your fingertips

Best-In-Class Solution and Support

Eon is always on and ready to help

From security, to implementation, to client support—Eon’s got you covered with:

  • HIPAA, HITECH Act, and SOC 2 Type II compliance
  • A cloud-based, AWS-hosted solution that requires no new hardware or on-premise maintenance
  • No workstation software loads
  • VPN connectivity to a HL7 feed from the EHR to AWS, can also include bi-directional HL7 integration (EPM to EHR) for integration of patient and provider letters in the EHR
  • Software updates and upgrades seamlessly rolled out free of charge
  • Multi-site deployment for hospital systems and IDNs with multiple facilities
  • Unlimited user access to the application with no additional cost
  • Quick implementation with ongoing client support
  • Less than 1-minute customer support response time

Ready to identify, track, and improve outcomes for patients at risk for future disease? Get started with your demo and ensure no patient falls through the cracks.